The various extracts of Tradescantia spathacea were investigated for its anti-arthritic activity in male albino rats. Freund’s adjuvant induced arthritis model was applied for the evaluation of anti-arthritic activity. Dexamethasone (0.1 mg/kg) was used as a regular drug. The ethanolic extract of T. spathacea exhibited significant anti-arthritic activity. The doses of 150 and 300 mg/kg of the ethanolic extract of T. spathacea, biochemical parameters assayed were rheumatoid factor, C-reactive protein (CRP), superoxide dismutase (SOD), catalase (CAT). The ethanol extract at the dose of 300 mg/kg body weight inhibited the rat paw edema, which is comparable with standard drug dexamethasone, inhibition of rat paw edema after 21 days. The results of the present investigation concluded, ethanol extract of T. spathacea possess a significant anti-arthritic activity against adjuvant induced arthritis and justifying its therapeutic role in arthritic condition.
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